Cerebrospinal fluid analysis in the 2010 revised McDonald's multiple sclerosis diagnostic criteria

Multiple Sclerosis Cerebrospinal Fluid Biomarkers

Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease ac...

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diag...

RAPID COMMUNICATION Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria

Chris H. Polman, MD, PhD, Stephen C. Reingold, PhD, Brenda Banwell, MD, Michel Clanet, MD, Jeffrey A. Cohen, MD, Massimo Filippi, MD, Kazuo Fujihara, MD, Eva Havrdova, MD, PhD, Michael Hutchinson, MD, Ludwig Kappos, MD, Fred D. Lublin, MD, Xavier Montalban, MD, Paul O’Connor, MD, Magnhild Sandberg-Wollheim, MD, PhD, Alan J. Thompson, MD, Emmanuelle Waubant, MD, PhD, Brian Weinshenker, MD, and J...

Cerebrospinal Fluid Proteomics of Multiple Sclerosis Patients

The cerebrospinal fluid in multiple sclerosis: far beyond the bands

The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers h...